YACHT2

• Research type

  Research Study

• Full title

  Young Adult Cardiovascular Health Trial 2

• IRAS ID

  146361

• Contact name

  Adam Lewandowski

• Contact email

  adam.lewandowski@cardiov.ox.ac.uk

• Sponsor organisation

  University of Oxford

• Clinicaltrials.gov Identifier

  NCT02103231

• Duration of Study in the UK

  3 years, 0 months, 1 days

• Research summary

  Study Design
  A case-control study reporting the associations between birth history, exercise capacity and cardiovascular function with reference to blood pressure in adults aged 18-40 years old.

  Background and Aims
  Studies tracking young people from birth into adulthood have identified premature birth to be associated with increased risk of high blood pressure and lower cardiovascular exercise capacity. Recently, we have reported that preterm birth or having a mother who had high blood pressure while pregnant can affect heart and blood vessel structure and function. We are now conducting a study to investigate if any of these features have an influence on exercise capacity or extend to involve the liver and brain.

  Study Participants
  The study will recruit 156 participants (78 preterm born, including 26 with hypertension and 78 with full term birth history, including 26 with hypertension.)
  Participants will be recruited via:
  1. Open advertising
  2. Hypertension Services at the John Radcliffe Hospital
  3. Previous study participants

  Study Procedures
  Participants will attend the Cardiovascular Clinical Research Facility, John Radcliffe Hospital for up to 2 study visits. Procedures during study visit one will include; measures of height; weight and skin fold thickness, donation of blood samples, completion of a study questionnaire, magnetic resonance imaging of the liver and heart, ultrasound imaging of the heart, measures of blood vessel structure and function, exercise testing and measures of physiological responses during exercise. Following the study visit participants will be asked to wear a heart rate monitor and a blood pressure monitor for 24 hrs. They will also be asked to wear an activity monitor to record their physical activity for 9 days. A subgroup of participants will be invited to attend an optional second visit to have brain magnetic resonance imaging.

  Study Management
  The study will be managed by the Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, University of Oxford. It is funded by the British Heart Foundation.

  Research Summary:

  The study demonstrated that people born preterm (less than 37 weeks of gestation, where normal gestation is between 37-42 weeks) have an impaired exercise capacity with a unique heart structure and function at rest and during exercise. Furthermore, preterm birth and heart disease risk were already associated with changes in brain structure in young adulthood.

• REC name

  South Central - Berkshire Research Ethics Committee

• REC reference

  14/SC/0275

• Date of REC Opinion

  29 May 2014

• REC opinion

  Favourable Opinion