Whole body vibration and plasma FGF23 concentrations

• Research type

  Research Study

• Full title

  The effect of whole body vibration on plasma FGF23 concentrations in children with chronic kidney disease

• IRAS ID

  127025

• Contact name

  Rodney Gilbert

• Contact email

  rodney.gilbert@uhs.nhs.uk

• Sponsor organisation

  University Hospital Southampton NHS Foundation Trust

• Research summary

  Patients with chronic kidney disease have high plasma levels of FGF23. The higher the levels, the greater the risk of dying. The optimal methods for reducing FGF23 levels are not known.

  We will ask patients to stand on a vibrating plate for 3 periods of 3 minutes each with 1 minute rest between sessions, five times per week for 4 weeks to see what effect this has on plasma FGF23. We will also ask patients to jump or skip daily for 10 minutes for 4 weeks. We will randomise patients to do jumping or vibrating plate first, then give them a 2 week rest period, then the other form of exercise.

  Blood will be drawn at the start and finish of each 4 week block of exercise for FGF23 levels.

• REC name

  South Central - Oxford A Research Ethics Committee

• REC reference

  14/SC/0096

• Date of REC Opinion

  19 May 2014

• REC opinion

  Further Information Favourable Opinion