WHiTE 8 COPAL

  • Research type

    Research Study

  • Full title

    WHiTE 8 COPAL: A Randomised Controlled Trial of low dose single antibiotic loaded cement versus high dose dual antibiotic loaded cement in patients receiving a hip hemiarthroplasty after fracture.

  • IRAS ID

    233884

  • Contact name

    Mike Reed

  • Contact email

    mike.reed@northumbria-healthcare.nhs.uk

  • Sponsor organisation

    Northumbria Healthcare NHS Foundation Trust

  • Duration of Study in the UK

    3 years, 8 months, 10 days

  • Research summary

    Hip fracture is a serious injury which mostly occurs in older patients. In the UK there are ~60,000 hip fractures every year. A hip fracture is a potentially catastrophic event; approximately 30% of patients will die during the first year following this injury and those that survive will have a significant reduction in their quality of life.\n\nThe most common type of hip fracture is treated with a partial hip replacement or hemi-arthroplasty. The hemi-arthroplasty can be fixed to the patient’s thigh bone with or without the use of ‘bone cement’, however a high percentage of these are fixed with cement. When fixing a broken hip with hemi-arthroplasty, a small percentage of patients experience Surgical Site Infection (SSI), a potentially catastrophic post-operative complication. In order to reduce the risk of infection, patients are given antibiotics. Antibiotics can also be added to the bone cement to help reduce the risk of infection.\n\nThis trial aims to compare two different antibiotic loaded bone cement mixtures used to hold a hemi-arthroplasty implant in place. The results of this trial should tell us if there is any difference in the rate of deep infection in patients when one of the two bone cement mixtures is used to hold their hemi-arthroplasty implant in place. The information gained will help patients and their doctors make more informed decisions about the best way to reduce the risk of infection in this type of surgery.\n

  • REC name

    Wales REC 5

  • REC reference

    18/WA/0154

  • Date of REC Opinion

    2 May 2018

  • REC opinion

    Favourable Opinion