What are the long-term health outcomes in psoriasis?
Research type
Research Study
Full title
Quantification of the long-term health consequences associated with psoriasis.
IRAS ID
124646
Contact name
Helen Young
Contact email
Sponsor organisation
The University of Manchester
Research summary
Psoriasis is an immune-mediated inflammatory disease which is currently incurable and occurs in 2-3% of the population of the UK. Emerging evidence demonstrates that patients with psoriasis are more likely to suffer from a number of co-morbid diseases such as cardiovascular disease, stroke, psychiatric illness (particularly depression), malignancy and diseases associated with immune dysfunction (e.g. ulcerative colitis).
At present there is limited information available on predictors of (i) psoriasis progression, (ii) outcomes that are important to patients and (iii) the association with different psoriasis-related co-morbidities. However, it may be possible to identify components of the psoriasis phenotype (clinical / genetic / biochemical) which could enable the long-term health consequences associated with psoriasis such as cardiovascular co-morbidity to be quantified.
The North West e Health (NWeH; Salford NHS and The University of Manchester) database is a unique resource which links primary care and secondary care datasets and thus provides an opportunity to compare a variety of clinical outcome measures and better understand their relationships.
This study proposes to use anonymised data from the NWeH database and Salford Integrated record (SIR) to identify a cohort of individuals with psoriasis who were initially recruited to a research study forming the basis of the Principle Investigator’s PhD (2001-3).
At recruitment to the 2001-3 PhD study, assiduous baseline clinical, genetic and biochemical phenotyping was performed. From December 2011 10 years will have elapsed from initial investigation of this cohort. This study will therefore determine whether there are features of the clinical / biochemical psoriasis phenotype which are predictive of the 10 year risk of incident psoriasis-related co-morbid disease such as coronary heart disease / cardiovascular events.
REC name
North West - Greater Manchester Central Research Ethics Committee
REC reference
14/NW/0222
Date of REC Opinion
16 May 2014
REC opinion
Favourable Opinion