VODECA
Research type
Research Study
Full title
Volatile Organic Compounds for Detection of Colorectal Cancer (VODECA)
IRAS ID
250738
Contact name
Chris Probert
Contact email
Sponsor organisation
University of Liverpool
Duration of Study in the UK
2 years, 11 months, 30 days
Research summary
Research Summary
Volatile Organic compounds for detection of colorectal cancer or the VODECA study is a case control study that aims to investigate volatile organic compounds (VOCs) associated with adenomas and early colorectal cancer (CRC) ultimately developing a panel of VOCs that can be used to select patients for colonoscopy to improve detection of colorectal neoplasia and reduce deaths from colon cancer.
We wish to recruit adult patients undergoing colonoscopy and patients being treated for colorectal polyps or cancer.
The study will be 3 years in duration.
Summary of Results
We are studying the compounds (metabolites) and bacteria in the stool (faeces) of patients with bowel cancer, those with polyps and a control group with no tumour / cancer.
Laboratory work is complete, but the data analysis is on-going.
At present, it appears there are differences in the faecal metabolites when patients have bowel cancer. In depth analysis looking at patients with serious polyps suggests a similar pattern.
Looking at bacteria, there are clear differences in faecal bacteria in patients with bowel cancer. Work to establish the link to polyps is on-going.
When the data analysis is complete, the report will be submitted to medical journals for publication.
REC name
East of England - Cambridgeshire and Hertfordshire Research Ethics Committee
REC reference
18/EE/0383
Date of REC Opinion
29 Nov 2018
REC opinion
Further Information Favourable Opinion