Vitamin D and Fibroids
Research type
Research Study
Full title
A pilot observational study investigating relationship between serum vitamin D and uterine fibroid volume and symptom severity score using validated uterine fibroid – quality of life questionnaire
IRAS ID
261391
Contact name
Alison Amoah
Contact email
Sponsor organisation
Imperial College London and Imperial College Healthcare NHS Trust
Clinicaltrials.gov Identifier
n/a , n/a
Duration of Study in the UK
0 years, 6 months, 28 days
Research summary
Uterine fibroids are common and can result in considerable morbidity for women. The underlying biology of fibroids are not well understood. There is some evidence that demonstrates an inverse relationship between levels of vitamin D in the bloodstream and uterine fibroid growth. Historically, research teams have described fibroid characteristics using ultrasound, which is readily available but limits accuracy. MRI of the pelvis with contrast (dye) improves characterisation of fibroids. Our specialist fibroid clinic is unique in that the majority of patients have fibroids characterised routinely by MRI pelvis to inform further treatment. We aim to carry out a prospective study investigating relationship between levels of vitamin D, calcium and parathyroid hormone in the bloodstream and uterine fibroid volume. In addition we will investigate to see if there is any correlation between vitamin D levels and symptom severity score using a validated uterine-fibroid quality of life questionnaire. To date, no other study has looked at the relationship between serum vitamin D on SSS/UF-QOL scores. This study would add to other studies implicating a role for vitamin D in the treatment /prophylaxis of mild-moderate uterine fibroids or potentially as a co-drug in more severe fibroid disease.
REC name
London - Westminster Research Ethics Committee
REC reference
19/LO/0525
Date of REC Opinion
30 Apr 2019
REC opinion
Further Information Favourable Opinion