Vibrational spectroscopy in disease of the vulva
Research type
Research Study
Full title
Evaluation of the role of vibrational spectroscopy in the assessment of vulval disease.
IRAS ID
162904
Contact name
Jonathan Frost
Contact email
Sponsor organisation
Gloucestershire Research Support Service
Clinicaltrials.gov Identifier
n/a, n/a
Research summary
Can vibrational spectroscopy be used to accurately assess vulval skin conditions?
Vulval skin disorders are common and the diagnosis of these conditions can be difficult. Reliable discrimination between benign vulval skin conditions, precancerous conditions or vulval cancer often requires tissue biopsies. In addition the monitoring of patients with vulval disease at risk cancerous change is currently limited to visual assessment often supplemented by multiple invasive tissue biopsies. There are currently no established non invasive tests available for the diagnosis of vulval skin diseases.
The vibrational spectroscopic techniques of Raman spectroscopy and Fourier transform infrared spectroscopy are non invasive diagnostic tools that use the interaction of light within tissues to identify the chemical composition of different tissues. The use of these tools may reduce the need for invasive biopsies to diagnose and monitor women with vulval skin disease.
The aim of this project is to explore the use of vibrational spectroscopic techniques in the diagnosis of vulval skin disease. This will be achieved by performing vibrational spectroscopy on samples of tissue previously taken from women with vulval skin disease treated at Gloucestershire Hospitals NHS Foundation Trust. The results of the spectroscopy will be compared with the routine tests and the accuracy of spectroscopy determined.
The study is funded by the Gloucestershire Hospitals NHS Foundation Trust Research and Innovation Forum.
REC name
East of Scotland Research Ethics Service REC 1
REC reference
14/ES/1066
Date of REC Opinion
20 Aug 2014
REC opinion
Favourable Opinion