Ventricular tachycardia ablation targets
Research type
Research Study
Full title
Dissecting the interaction between dynamic myocardial electrophysiology and sympathetic inputs to identify new therapeutic targets in human ventricular arrhythmia
IRAS ID
226988
Contact name
Claire A Martin
Contact email
Sponsor organisation
Papworth Hospital NHS Foundation Trust
Duration of Study in the UK
8 years, 0 months, 1 days
Research summary
Heart disease remains a leading cause of death worldwide, and often this is due to rhythm abnormalities (arrhythmias) in the ventricles (lower chambers) of the heart which prevent sufficient blood circulating around the body.
Current treatments involve passing wires (catheters) into the heart to modify (ablate) these areas of scar to prevent abnormal rhythms starting. Unfortunately, 50% of patients undergoing this type of operation develop further arrhythmias over 2 years, and current procedures take a long time and incur significant risk. Therefore the aim of my research is to develop more effective and safer treatments for ventricular arrhythmias.
Patients with heart disease who are undergoing ablation procedures for ventricular arrhythmias will be eligible to participate in the study. The study will be conducted at Papworth Hospital and Addenbrookes Hospital. The study will last 5 years. We aim to recruit 150 participants.
We will use scans of the heart as well as mapping technology which can record electrical signals from inside the heart to provide detailed information about the location of scar and nerves supplying the heart. This will lead to a better understanding of how abnormal rhythms can start and can enable us to plan improved treatments.
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
17/EE/0420
Date of REC Opinion
18 Dec 2017
REC opinion
Unfavourable Opinion