Venous Thromboembolism Database
Research type
Research Database
IRAS ID
160232
Contact name
Khalida Ann Lockman
Contact email
Research summary
Venous Thrombus Embolism Register Edinburgh
REC name
West of Scotland REC 5
REC reference
15/WS/0206
Date of REC Opinion
27 Oct 2015
REC opinion
Favourable Opinion
Data collection arrangements
It is estimated that 25,000 people die every year from preventable blood clots in the vein. We wish to establish a database or register of patients referred to the Department of Acute Medicine or Department of Radiology at the Royal Infirmary of Edinburgh with potential blood clot (venous thrombosis (VTE)). This database will allow us to look at short and long-term outcomes of treatments as well as to determine factors that can influence these outcomes. Clinical details and results of clinical tests will be entered into this database. This will include age, gender, postcode, weight, height, lifestyle (alcohol and smoking) history, past medical history, risk factors for DVT, investigations (blood and scan) results, duration and type of blood thinning treatments, and long-term outcomes. All cases will be followed up for five years to determine the rate of death (primary outcome) and other outcomes including recurrence of blood clots and new diagnosis of cancer. Informed consent will be obtained from potential participants. Data will be linked to form an electronic register on a secure server in NHS Lothian. Additionally, we are seeking support from the Lothian Research Safe Haven to ensure complete data security.
Research programme
Venous thrombosis or clots in the veins remains a significant health problem. Formed in the deep veins, a clot can potentially detach and travel to the blood vessels in the lungs giving rise to pulmonary embolus (PE). In the United Kingdom alone, deep venous thrombosis (DVT) and PE results in 25 000 deaths. In our previous study, the five-year mortality of patients attending the ambulatory care at the Royal Infirmary of Edinburgh with DVT was 26.5%. This research project is focused on developing a database of patients referred with clinical symptoms and signs of clot in the deep veins. Our main objectives are two-fold. First, we wish to examine long-term outcomes of DVT and factors including obesity and diabetes on the outcomes of DVT. Additionally, the data will allow us to examine the outcomes of patients with increased blood marker for clots (D-dimer) but without radiological evidence of DVT. Second, The database will streamline all data thus establishing a platform for further studies that can improve clinical care for patients with DVT.
Research database title
Venous Thrombus Embolism Register Edinburgh
Establishment organisation
NHS Lothian
Establishment organisation address
Royal Infirmary of Edinburgh
51, Little France Crescent,
Edinburgh
EH16 4SA