Vasopressin in Acute Myocardial Infarction
Research type
Research Study
Full title
Role of vasopressin in myocardial ischaemia/reperfusion injury
IRAS ID
216548
Contact name
Ioakim Spyridopoulos
Contact email
Sponsor organisation
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 11 months, 30 days
Research summary
Coronary heart disease is a condition in which proper circulation of blood and oxygen is not provided to the heart. This is due to a narrowing of the small blood vessels (arteries), which normally supply the heart with blood and oxygen. A heart attack is caused when one of the arteries supplying the heart becomes blocked. Modern treatment of heart attacks involves opening the blocked artery with a balloon and placing a stent (a small metal tube) in the artery to hold it open.
Recently, research has shown that after opening the artery the heart muscle continues to be damaged by a phenomenon called ischaemia reperfusion injury. The coronary microvessels which are too small to visualise and treat with stents have previously been shown to be involved in this process.
Vasopressin is a hormone produced by the body, and it is shown to constrict the microvessels further and lead to larger heart attacks. There is some data that shows that Vasopressin levels are very high at the time of a heart attack. The role of our study is to investigate vasopressin and the microvasculature and to explore this area further, to see if we can look at novel ways to reduce the size of the heart attack with future studies.
For this study, we will include consenting patients presenting with full blown heart attacks undergoing treatment for coronary heart disease by percutaneous coronary intervention at Freeman Hospital. We will obtain several blood samples before and after stent implantation. From their blood samples we will investigate the distribution of vasopressin, whilst measuring microvascular resistance with a wire inside the coronary artery.
R&D Reference :- 8171
REC name
North East - Newcastle & North Tyneside 2 Research Ethics Committee
REC reference
16/NE/0405
Date of REC Opinion
3 Feb 2017
REC opinion
Further Information Favourable Opinion