Vascular Function in Coarctation of the Aorta
Research type
Research Study
Full title
Exploring the life course of hypertension in corrected coarctation of the aorta: Pathophysiological insights into the mechanisms leading to persistent hypertension
IRAS ID
288944
Contact name
Gregory Lip
Contact email
Sponsor organisation
University of Liverpool
Duration of Study in the UK
1 years, 0 months, 30 days
Research summary
Some people are born with heart defects where the main tube (aorta) taking blood away from the heart is not as wide as it should be, resulting in an increase in blood pressure to enable the heart to supply the body with enough blood in every heartbeat. This heart defect can be fixed, usually soon after birth, with an operation to widen the aorta either directly or with a patch. After this operation, blood pressure no longer needs to be high but sometimes it stays high. It is not known why some people’s blood pressure stays high and some return to normal, but those with high blood pressure need treatment as this increases the risk of heart attacks and strokes in adulthood. One reason for the different response of blood pressure following the operation might be because the blood vessels in the body respond differently to changes in blood flow in those with high blood pressure. In this study, we will investigate the response of the blood vessels in the brain and limbs to changes in blood flow. We will compare these responses between children and adults who have had an operation to fix the heart defect and have both normal and high blood pressure. We will also compare these changes to individuals who have high blood pressure due to other causes. Together, this information will provide insight into how to test those that will get high blood pressure and how to better treat the high blood pressure.
REC name
Wales REC 3
REC reference
21/WA/0318
Date of REC Opinion
1 Dec 2021
REC opinion
Further Information Favourable Opinion