Vascular dysfunction in Paediatric IBD (V1)

• Research type

  Research Study

• Full title

  Investigation of vascular endothelial dysfunction, thromboembolism and structural arterial disease in Paediatric and Adolescent Inflammatory Bowel Disease (IBD)

• IRAS ID

  135416

• Contact name

  Steven Ariss

• Contact email

  s.ariss@sheffield.ac.uk

• Sponsor organisation

  UCL Institute of Child Health

• Research summary

  Inflammatory Bowel Diseases (IBD) is a group of relapsing and remitting gut inflammatory conditions acquired due to genetic susceptibility and/or environmental triggers. The disease manifestations are being increasingly seen in young children and the life-long debilitation has a severe effect on quality of life. Limited evidence suggests, although rare, in some young IBD individuals vascular complications may ensue. This leads to increased risk of vascular problems such as thrombosis, arterial disease and stroke.
  In the present project we aim to study and highlight potential vascular changes in young IBD patients and compare these changes with age and gender matched controls. Vasculature will be measured in multiple ways including blood analysis in the laboratory and non-invasive, physiological measures of arterial health (e.g. ultrasound arterial scan). Our overall goal is to identify biomarkers indicative of increased risk of vascular dysfunction as this will open new avenues for early therapeutic intervention

• REC name

  London - Brent Research Ethics Committee

• REC reference

  14/LO/0644

• Date of REC Opinion

  20 Jun 2014

• REC opinion

  Further Information Favourable Opinion