Variable liver function and coagulation
Research type
Research Study
Full title
Liver Function and Coagulation: Causes and Effect of Individual Biomarker Variation
IRAS ID
100165
Contact name
Catherine Rea
Contact email
Sponsor organisation
Kings College Hospital NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Liver function tests (LFT’s) are routinely measured in clinical practice to monitor the health and function of the liver. Variation in these tests occurs due to liver damage, but can also fluctuate in healthy individuals; both those enrolled on clinical trials and in the context of population studies. Environmental factors including diet, medication or drugs, thyroid function, obesity, exercise, alcohol, smoking and caffeine have all been identified as being associated with variation in laboratory measurements of liver function.
The liver has many vital functions. A key function is to produce clotting factors; the proteins in the blood required to form blood clots and stop bleeding following injury. Liver damage is known to affect the ability of the liver to produce clotting factor proteins. However, it is not known if the daily fluctuations of liver function, seen in healthy individuals, has an effect on the clotting factor levels.
This study therefore aims to explore the possibility that day to day fluctuations in liver function tests is associated with variation in clotting factor levels and other biomarkers .
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
20/LO/0468
Date of REC Opinion
18 Mar 2020
REC opinion
Favourable Opinion