Validating MRI muscle analysis in peripheral nerve injury
Research type
Research Study
Full title
Validating quantification MRI muscle analysis in denervation renervation; Developing a clinical tool to predict the success of nerve repair using quantitative MR (qMRI) data- Signal change and volumetrics.
IRAS ID
235012
Contact name
Tom Quick
Contact email
Sponsor organisation
Royal National orthopaedic hospital
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Nerve injury is a common and debilitating condition that can leave muscles paralysed.
The process of muscle reinnervation is one which is key to rehabilitation and recovering function. The processes have been well studied in animal models and we wish to develop tools to allow us to noninvasively collect the same parameters in human subjects to inform clinical care.
Non-invasive Quantitative MR (Q-MRI) technologies (both signal and volumetric analysis) over time are likely to serve as useful tools in better understanding the process of muscle reinnervation by utilisation of a standardised surgical model. By extension, this technique will offer clinical data to assess current state, follow recovery and after when linked with outcomes may offer a way of predicting outcome and assisting in decision-making.
These qMRI parameters may serve as a clinical model through which the success of surgical nerve repair can be predicted and provide a valuable secondary outcome measure in future clinical trials.
REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
17/YH/0413
Date of REC Opinion
22 Dec 2017
REC opinion
Further Information Favourable Opinion