Vaildation of circulating biomarkers to diagnose early onset of sepsis

• Research type

  Research Study

• Full title

  Advancing biomarker use in sepsis management: validation of circulating biomarkers to diagnose the early onset of sepsis.

• Contact name

  Paul Dark

• Contact email

  paul.m.dark@manchester.ac.uk

• Sponsor organisation

  Salford Royal NHS Foundation Trust

• Research summary

  The proposed project will seek to obtain blood samples from patients in critical care who are showing no evidence of a systemic inflammatory response (SIRS)based on the absence of internationally recognised clinical signs (the SIRS criteria). These samples will be used as controls for ongoing studies investigating the potential usefulness of circulating biomarkers for rapid differential diagnosis of patients with an inflammatory response driven by infection (sepsis) from patients with a sterile systemic inflammatory response (SIRS) or patients with no inflammatory response. Samples will also be used for biomarker assay development and optimisation within the context of this study

• REC name

  North West - Greater Manchester South Research Ethics Committee

• REC reference

  13/NW/0161

• Date of REC Opinion

  6 Jun 2013

• REC opinion

  Further Information Favourable Opinion