Utility of near infrared spectroscopy in mitochondrial disease - V4.6

• Research type

  Research Study

• Full title

  Utility of the vascular occlusion test (VOT) with Near infrared spectroscopy (NIRS) in detecting abnormal tissue oxygen consumption in patients with mitochondrial disease

• IRAS ID

  128614

• Contact name

  Mark Peters

• Sponsor organisation

  University College London - Institute of Child Health

• Research summary

  The human body is made of millions of cells. All cells contain energy producing machine called Mitochondria. Mitochondria produce energy by utilizing oxygen and food (Carbohydrates and fats). In some people, mitochondria do not work properly and may not use oxygen efficiently.
  Currently, doctors have to do tests on a sample of muscle from these people to find out (diagnose) the mitochondrial disease. They look for the amount of oxygen used by the mitochondria in the muscle sample. Unfortunately, doctors have to cut the skin to get the muscle sample. These tests are complex and results take a long time.
  We want to use another machine to help find out about these disease without the need for a muscle test. This machine (called a near infrared spectroscope or NIRS) will measure the amount of oxygen used in the muscle. The amount of oxygen used can give us an idea of how well mitochondria are working. This will help with diagnosis.

• REC name

  London - Camden & Kings Cross Research Ethics Committee

• REC reference

  13/LO/1259

• Date of REC Opinion

  4 Oct 2013

• REC opinion

  Further Information Favourable Opinion