Urinary Proteomic analysis for Obstructive Sleep Apnoea:followup study
Research type
Research Study
Full title
Urinary Proteomics based on Capillary Electrophoresis-Coupled Mass Spectrometry in obstructive sleep apnoea with obesity: Follow-up study
IRAS ID
134756
Contact name
John Wilding
Contact email
Research summary
In a previous study, we investigated the use of a technique called capillary-electrophoresis mass spectrometry in order to study urinary protein patterns in obese patients with and without Obstructive Sleep Apnoea (OSA). This study has since been completed.
In the current study, the research question being addressed is: whether and how urine protein profiles change with and without continuous positive airway pressure (CPAP) treatment in obese subjects with OSA and controls, using subjects from the original cohort of our first study.
Obstructive Sleep Apnoea occurs when patients have fragmented sleep breathing patterns and research has shown that it is associated with cardiovascular disease. The treatment for OSA is CPAP (where patients where a mask which delivers a positive airway pressure to keep airways patent). In our initial study, we sought to study the urine protein patterns in obese patients with and without OSA. In order to assess whether these profiles change over time, we wish to follow-up the patients from the initial cohort and study their urine protein patterns to see if this has changed with treatment; and for those not on treatment, whether this has changed with time.
The study of proteins is called ’proteomics’. By further studying urinary protein patterns following OSA treatment, we seek to determine if these urinary biomarkers are affected by treatment.
This study will involve 90 patients from our initial study. Patients will attend for a single study day where urine and blood samples will be taken. Urine samples will subsequently be processed by capillary-electrophoresis mass spectrometry which is a technique used to study proteins.REC name
North West - Preston Research Ethics Committee
REC reference
13/NW/0589
Date of REC Opinion
29 Aug 2013
REC opinion
Favourable Opinion