Urinary micronutrient profile as AKI biomarker in coronary angiography
Research type
Research Study
Full title
A pilot study to investigate urinary micronutrient profile as an early biomarker of acute kidney injury following coronary angiography
IRAS ID
190342
Contact name
Mark Devonald
Contact email
Sponsor organisation
Nottingham University Hospitals NHS Trust
Duration of Study in the UK
1 years, 2 months, 1 days
Research summary
Acute kidney injury (AKI) is the rapid deterioration in kidney function over hours or days. It is a common problem that is associated with significant morbidity and mortality and affects approximately 10-20% hospital admissions.
AKI is currently identified using blood tests (serum creatinine levels) and urine output. Both of these are delayed markers of AKI. There is an urgent need for a reliable early test (biomarker), to allow earlier detection of AKI. In research using pigs to study AKI we have identified that urinary micronutrient profile (including amino acids, vitamins and trace elements) may have a role as a novel early biomarker of AKI. This study will investigate whether these biomarkers predict development of AKI and how serious it is.
This study involves analysing urine samples from adult patients who have undergone a coronary angiogram (an x-ray test to look at the blood supply to the heart) following a heart attack. This group of patients is recognised to be at relatively high risk of developing AKI. It is an observational study and so will not require any extra intervention or deviation from standard care. We will take samples of urine once before and twice after the angiogram, measure the urine volume and analyse the micronutrient profile. If the patient has a urinary catheter we will take samples from the catheter every hour and measure urine output. We will review routine daily blood tests (serum creatinine) for the duration of the admission (or for 5 days and then again on discharge) to identify cases where AKI occurs. Follow up blood tests will be done on the 5th and 30th day after the test. Exceptionally an additional blood test may be required if blood tests are not measured daily.
REC name
North West - Preston Research Ethics Committee
REC reference
15/NW/0799
Date of REC Opinion
29 Sep 2015
REC opinion
Favourable Opinion