Urinary micronutrient profile after renal transplantation
Research type
Research Study
Full title
Urinary micronutrient profile as an early biomarker for acute tubular injury after renal transplantation
IRAS ID
190504
Contact name
Mark Devonald
Contact email
Sponsor organisation
Nottingham University Hospitals NHS Trust
Duration of Study in the UK
4 years, 0 months, 0 days
Research summary
Kidney transplantation is the best treatment for many patients with kidney failure. A successful kidney transplant can improve quality of life and reduce the risk of dying, when compared with long term dialysis treatment.
After kidney transplant surgery, sometimes the kidney does not start to work straight away. We assess how well the new kidney is working by measuring blood tests (particularly creatinine) regularly after the surgery and by measuring the amount of urine produced. At present, we do not have a reliable blood or urine test to predict whether there is likely to be a delay before the new kidney starts to work.
In research using pigs to study kidney failure we have identified substances in urine (including vitamins and minerals) which may help us to detect kidney damage early and which might be of use after kidney transplantation to predict whether the kidney will work straight away. Early detection of possible delayed kidney function might lead to some changes in tests and treatment. This study will investigate whether these substances in urine predict development of delayed kidney function and how serious it is.
The study involves analysing urine samples from adult patients who have been admitted for a kidney transplant. It is an observational study so will not require any intervention or changes from routine care. It is standard practice for patients to have a catheter placed into the bladder for measuring urine production after their kidney transplant. We will take regular samples from the catheter after the operation, and we will measure the hourly urine output. We will review routine daily blood tests (blood creatinine) for the duration of the admission (or for 5 days and then again on discharge). Follow up blood tests will be reviewed 30 days and 1 year after the operation.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
16/EM/0031
Date of REC Opinion
8 Jan 2016
REC opinion
Favourable Opinion