Urinary excretion of aluminium and silicon in multiple sclerosis.

• Research type

  Research Study

• Full title

  Urinary excretion of aluminium and silicon in secondary progressive multiple sclerosis.

• IRAS ID

  144340

• Contact name

  Christopher Exley

• Contact email

  c.exley@keele.ac.uk

• Sponsor organisation

  Keele University

• Research summary

  The primary aim of the research is to study the renal handling of silicon (Si), imbibed as a silicon-rich mineral water, through the measurement of its urinary excretion over time. Additional variables will include urine creatinine (Crt) and urinary excretion of aluminium (Al) and iron (Fe) in patients with secondary progressive Multiple Sclerosis (SPMS).
  The research will monitor the urinary excretion of Si, Al and Fe over time to establish if there are any relationships between the urinary excretion of each of these three elements.

  A secondary aim is to study the clinical relevance of urinary excretion status of Si, Al and Fe. We would like to explore if Si-rich mineral water consumption and any resultant changes in urinary excretion of Si, Al and Fe, are associated with changes in clinical parameters specifically cognitive and physical performance of MS patients.

• REC name

  Yorkshire & The Humber - South Yorkshire Research Ethics Committee

• REC reference

  14/YH/1115

• Date of REC Opinion

  25 Sep 2014

• REC opinion

  Further Information Favourable Opinion