UPrEP
Research type
Research Study
Full title
Understanding the relationship between HIV pre-exposure prophylaxis, sexually transmitted infections and antibiotic resistance in Wales.
IRAS ID
281194
Contact name
Adam D N Williams
Contact email
Sponsor organisation
Cardiff University
Duration of Study in the UK
1 years, 11 months, 30 days
Research summary
HIV pre-exposure prophylaxis (PrEP) is used for preventing the infection of HIV and is currently provided to all high-risk individuals in Wales. Some clinicians and academics have theorised that PrEP will lead to an increase in sexually transmitted infections and in turn, increase antibiotic resistance through decreased condom use. Stage one of this project aims to look at the longitudinal trends in sexually transmitted infections and antibiotic resistance among gay and bisexual men in Wales over the past 5 years. This epidemiological study will use secondary data from Public Health Wales. The data is routinely collected from GUM clinics across Wales and sent to Public Health Wales for examination. The data is identified anonymised by clinic reference numbers. An interrupted time series analysis will be used comparing both PrEP users and non-PrEP users before and after PrEP was introduced. Some previous studies have identified potential increases in sexually transmitted infections due to PrEP but have been criticised for not accounting for biases within the data. These biases include sample bias and surveillance bias which this study will adjust for in its analysis.
REC name
N/A
REC reference
N/A