Untargeted metabolomics of serum samples during COVID-19 [COVID-19]
Research type
Research Study
Full title
Untargeted metabolomics of serum samples during COVID-19
IRAS ID
284728
Contact name
Andrew Davison
Contact email
Sponsor organisation
Royal Liverpool and Braodgreen University Hosptal Trust
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Understanding changes in the biochemistry of an individual who is ostensibly healthy, including when they may show no overt symptoms of infection with SARS-CoV2, remains a huge challenge. Similar questions apply to understanding who is likely to live (unaided or via intervention) and who will die from COVID-19 once diagnosed, and the answers are equally unknown. Since we have limited knowledge presently, although we know that there are cardiovascular changes that should have easily measured metabolic consequences, the best approach is to measure everything and find out.\n\nPotential benefits from this work include early detection of metabolic changes following confirmed infection and overt COVID-19 disease. The deliverables will be knowledge of metabolic rules, against an individual’s baseline, that are prognostic of SARS-CoV2 infection, its progression, and its outcomes. This information can be used to triage patients into high-, medium- and lower-risk groups, and as such help direct therapy during disease progression. [Study relying on COPI notice]
REC name
North West - Haydock Research Ethics Committee
REC reference
20/NW/0332
Date of REC Opinion
17 Jul 2020
REC opinion
Favourable Opinion