Understanding Pneumococcal Carriage and Disease
Research type
Research Study
Full title
Cross-sectional study to establish the point prevalence of serotype 19A pneumococcal nasopharyngeal carriage of fully vaccinated children aged 13-48 months following introduction of PCV13.
IRAS ID
134935
Contact name
Andrew Pollard
Contact email
Sponsor organisation
Clinical Trails and Research Governance
Research summary
Pneumococcal carriage in the Thames Valley region has been studied over the last 12 years with carriage rates having been shown to be reflective of IPD potential and hence vaccine effect. During this time pneumococcal conjugate vaccines have been introduced into the routine immunisation schedules of this community. The PCV7 vaccine has subsequently been noted to have had a significant impact in reducing vaccine serotype carriage and IPD. Herd protection has also been implicated with vaccine serotypes not being carried in parents of vaccinated children. The most common serotype carried since the introduction of PCV7 is 19A, which is included in the PCV13 vaccine. PCV13 has superseded PCV7 in the routine immunisation schedule, however its impact on carriage and IPD in this community is yet to be evaluated.
REC name
South Central - Oxford A Research Ethics Committee
REC reference
13/SC/0578
Date of REC Opinion
7 Nov 2013
REC opinion
Favourable Opinion