Understanding Leucocyte Function
Research type
Research Study
Full title
Leucocyte Function in Health and Disease
IRAS ID
243980
Contact name
Charlotte Summers
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
Clinicaltrials.gov Identifier
204017/Z/16/Z, Medical Research Council; 204017/Z/16/Z, Wellcome Trust PhD Programme for Clinicians; N/A, Experimental Medicine Initiative to Explore New Therapies (EMINENT); N/A, NIHR BRC Cardiovascular & Respiratory Theme
Duration of Study in the UK
3 years, 10 months, 1 days
Research summary
Leucocytes (white blood cells) play an important role in numerous lung diseases and inflammatory conditions such as asthma, COPD, emphysema and rheumatoid arthritis. The aim of the study is to understand the underlying differences between leucocyte function in patients with inflammatory disorders and in healthy volunteers. Leucocytes can be obtained from inflammatory tissue such as pleural fluid, bronchoalveolar lavage (BAL) abscess fluid, synovial fluid, urine, sputum and oral cavity samples as well as blood. In this study we will extract the relevant leucocytes from these inflammatory tissues and test how these leucocytes behave compared to healthy cells. The further understanding of leucocyte biology and genetics is essential in the future development of new target therapies.
REC name
North West - Greater Manchester Central Research Ethics Committee
REC reference
22/NW/0028
Date of REC Opinion
15 Feb 2022
REC opinion
Further Information Favourable Opinion