UK FaND Study: Fibrin clot structure / function and NETosis in patients with Diabetic Foot Ulcer

• Research type

  Research Study

• Full title

  UK FaND Study: Fibrin clot structure/function and NETosis in patients with Diabetic Foot Ulcers

• IRAS ID

  154079

• Contact name

  Zoe Dong Yang Sun

• Sponsor organisation

  Leeds Teaching Hospitals NHS Trust

• Clinicaltrials.gov Identifier

  N/A, N/A

• Duration of Study in the UK

  3 years, 0 months, 31 days

• Research summary

  Diabetes is becoming an increasing problem. Diabetic foot ulcers are the most exhaustive of all diabetic complications on the National Health budget. Diabetic patients with foot ulcers are more likely to lose their leg, and die from a heart attack or stroke than diabetic patients without foot ulcers. We know from current research that blood thickness and the tendency to form blood clots in diabetic patients is higher than in patients without diabetes. From this, our theory is that foot ulcer disease alters the thickness and quality of blood which contribute to the excess risk of leg loss, heart attack and stroke. We therefore set to take blood samples and make measurements on diabetic patients with foot ulcer disease, follow them through time and make further measurements after treating an infection and after their foot ulcer has healed. This can be compared to the initial blood for quality and thickness to see whether there is a difference. This would contribute to our understanding of the disease process and enable us to find potential targets for treatment in preventing or reducing death and leg loss in diabetics with foot ulcer disease.

• REC name

  Yorkshire & The Humber - Leeds West Research Ethics Committee

• REC reference

  15/YH/0197

• Date of REC Opinion

  9 Sep 2015

• REC opinion

  Further Information Favourable Opinion