Type 2 Diabetes in Aortic Stenosis (DAS)
Research type
Research Study
Full title
The Impact of Type 2 Diabetes on Cardiac Metabolic Phenotype in Patients with Severe Aortic Stenosis
IRAS ID
252633
Contact name
Sven Plein
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
The aging of the population results in increasing numbers of patients suffering with narrowing of the aortic valve (aortic stenosis- AS). AS limits the blood flowing through the valve, forcing the heart to work harder to maintain its pumping function. Valve replacement surgery is needed when the valve becomes too narrowed. One in 5 AS patients has diabetes. Diabetes is linked to increased risk of death after surgery for AS. Why diabetic patients with AS have higher health risks is not understood. In diabetes, patients’ hearts are over-reliant on burning fats for energy, rather than sugars. In AS, patients’ hearts lose the capacity to burn fat for energy. It is important to understand how exactly these conditions together affect the heart before considering fat-busting drug interventions. In the proposed research, we will recruit patients who have Type 2 diabetes (T2D) and AS as well as patients who have AS but not T2D and are scheduled for valve replacement surgery.This study will aim to understand the effects of T2D and AS on the heart by evaluating the heart’s use of fat and sugar in a small sample of heart muscle obtained during the surgery for AS, and using MRI scans and exercise testing to assess the heart’s energy status, fat levels, and function before and 6 months after the surgery. The exercise test will evaluate the distance a patient can walk within 6 minutes under the supervision of a health care professional (6 minute walk test). A small amount of blood will be obtained for testing for proteins and molecules as health indicators. A small amount of urine sample will be collected to assess the presence of a protein leak from the kidneys.
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
18/YH/0442
Date of REC Opinion
3 Dec 2018
REC opinion
Favourable Opinion