Troponin release after anthracyclines in children (pilot study)
Research type
Research Study
Full title
Troponin release after anthracycline treatment in children (pilot study): An investiagtion into the frequency and timing of Troponin T release following anthracycline chemotherapy in paediatric oncology
IRAS ID
117259
Contact name
J Vormoor
Contact email
Sponsor organisation
Newcastle upon Tyne Hospitals NHS Foundation Trust
Research summary
Anthracyclines are a class of highly effective chemotherapy drugs, widely-used in adults and children. One of their major side-effects is long-term damage to the heart and this limits the total dose that can be given.
Cardiac troponins are proteins which regulate heart contraction. They are released into the blood stream after heart damage such as a heart attack.
This study will investigate the release of cardiac troponin T in children after anthracycline chemotherapy by testing for troponin using a high-sensitivity assay in blood samples which are already taken routinely as part of standard clinical care.
This pilot study will document the frequency and timing of troponin release in children being treated with anthracyclines to help design an interventional study designed to prevent heart damage in these children. We hypothesise that the detection of troponin will act as an ‘early warning’ of heart damage and guide specific protective treatments and/or change to chemotherapy regimens.REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
13/NE/0228
Date of REC Opinion
1 Oct 2013
REC opinion
Further Information Favourable Opinion