Trial of Proton Pump Inhibitors in Throat Symptoms

• Research type

  Research Study

• Full title

  A randomised, placebo controlled trial of extra-oesophageal reflux treatment in the management of upper respiratory symptoms. [TOPPITS: Trial of Proton Pump Inhibitors in Throat Symptoms]

• IRAS ID

  137605

• Contact name

  Janet Wilson

• Contact email

  janet.wilson@ncl.ac.uk

• Eudract number

  2013-004249-17

• ISRCTN Number

  N/A

• Research summary

  The TOPPITS trial aims to quantify, and to characterise, the effect of proton pump inhibitor therapy compared to placebo. Our comprehensive package of patient centred outcomes allow us to assess which specific throat symptoms respond; whether any patient characteristics can predict such a treatment response, derive improved estimates of impact on quality of life, and define the proportion of likely non-responders, for whom alternative therapeutic approaches may be more appropriate.

• REC name

  North East - Tyne & Wear South Research Ethics Committee

• REC reference

  13/NE/0336

• Date of REC Opinion

  2 Dec 2013

• REC opinion

  Favourable Opinion