Transcriptional control of the circadian clock and rAML
Research type
Research Study
Full title
Mechanisms linking transcriptional control of the circadian clock and radiation-induced leukaemia
IRAS ID
325587
Contact name
Grainne O'Brien
Contact email
Sponsor organisation
UK Health Security Agency
Duration of Study in the UK
4 years, 11 months, 31 days
Research summary
Exposing ourselves to inappropriate light, travelling across time zones and shift work negatively impacts our health. The circadian timing system is a complex biological network of interacting circadian clocks that regulates 24 hours rhythms of behavioural and physiological processes. Alterations of the circadian clock have been linked to cancer development and core circadian clock transcription factors have been shown to act as tumour-suppressors with deletion of PER2 promoting cancer following exposure to IR.
We wish to use blood samples from people in occupations involving shift work to investigate the disruption to circadian gene expression, the response to radiation and if this disruption has a mechanistic link to cancer, specifically radiation-induced acute myeloid leukemia. The results will inform us on the of risks of circadian disruption and allow us to design and provide accurate scientific and health advice to the government and the public.REC name
North East - Newcastle & North Tyneside 2 Research Ethics Committee
REC reference
23/NE/0166
Date of REC Opinion
1 Nov 2023
REC opinion
Further Information Favourable Opinion