Tranexamic acid in Intracerebral Haemorrhage (TICH)

• Research type

  Research Study

• Full title

  A randomised controlled trial of Tranexamic acid in Intracerebral Haemorrhage (TICH)

• IRAS ID

  57650

• Contact name

  Nikola Sprigg

• Sponsor organisation

  University of Nottingham

• Eudract number

  2010-022009-16

• ISRCTN Number

  Not available

• Research summary

  Haemorrhagic stroke, caused by bleeding in the brain, can be devastating and is a common cause of death and disability. There is no proven effective treatment for haemorrhagic stroke. Outcome after haemorrhagic stroke is closely related to whether the bleeding in the brain expands after onset, with a bad outcome (death and disability) being more likely to occur in patients who suffer expansion of the bleeding. Clinical trials have assessed drugs aimed at preventing expansion of the bleeding by speeding up blood clotting processes in the brain, but so far no drugs have been effective. Tranexamic acid (TA) is a drug that can be given as a tablet or injection (IV) and is used in a number of bleeding conditions to reduce bleeding. It has been used in subarachnoid haemorrhage (bleeding around the surface of the brain) to try to prevent re-bleeding. To date it has not been tested in haemorrhagic stroke.

• REC name

  East of England - Cambridge Central Research Ethics Committee

• REC reference

  10/H0308/80

• Date of REC Opinion

  1 Nov 2010

• REC opinion

  Further Information Favourable Opinion