Total inhibin and CA125 in ovarian cancer
Research type
Research Study
Full title
Early detection of granulosa cell tumours and mucinous ovarian cancers by total inhibin and CA125
IRAS ID
133116
Contact name
Usha Menon
Contact email
Sponsor organisation
UCL
Research summary
Granulosa cell tumours (GCT) are rare ovarian tumours representing 25%
of all ovarian cancers. The 5year survival rate if detected at early stage (I/II) is 75-95%, and 22-50% in late stage (III/IV) disease. It has been previously shown
that total inhibin is a specific marker of granulosa cell tumours (GCT) and compliments CA125 in the detection of mucinous ovarian tumours (Robertson, Pruysers et al. 2007). The combination of CA125 and total inhibin has high sensitivity (99%) and specificity (98%) when tested in clinical samples from women diagnosed with late stage disease. However, there is currently limited data available on the performance of inhibin in detection of early stage disease. The UKCTOCS serum bank provides a unique opportunity to assess the performance of total inhibin combined with CA125 using preclinical samples. Serum samples have been collected from women taking part in the ovarian cancer screening trial (UK Collaborative
Trial of Ovarian Cancer Screening, UKCTOCS) where 202,638 women from the general population were randomised to (1) screening with serum CA125 followed by transvaginal scan (TVS) as a second line test (Multimodal group), (2) screening with TVS (Ultrasound group), or control group in 1:1:2 ratio. Women were recruited between 2001 and 2005 and screened annually up to 31st December 2011. A nested case control study of up to 100 women with GCT or mucinous tumours who had samples taken prior to diagnosis and control samples from apparently healthy women and those who had benign ovarian neoplasms following surgery on the trial would be included. For the cases from the multimodal group of the trial, serial samples predating diagnosis will be included.REC name
East Midlands - Derby Research Ethics Committee
REC reference
13/EM/0282
Date of REC Opinion
4 Jul 2013
REC opinion
Favourable Opinion