To assess the clinical utility of Adaptive Optics versus other imaging
Research type
Research Study
Full title
To assess the clinical utility of Adaptive Optics versus other imaging modalities in managing retinal conditions.
IRAS ID
269708
Contact name
Andrew Lotery
Contact email
Sponsor organisation
University Hospital Southampton NHS Foundation Trust
Clinicaltrials.gov Identifier
1, Bek, T. Fine Structure in Diabetic Retinopathy Lesions as Observed by Adaptive Optics Imaging. a Qualitative Study. Acta Oph-thalmologica 92, 753–758 (2014); 2, Lombardo, M. et al. Adaptive Optics Imaging of Parafoveal Cones in Type 1 Diabetes. Retina 34, 546–557 (2014); 3, Paques, M. et al. Adaptive Optics Ophthalmoscopy: Application to Age-Related Macular Degeneration and Vascular Diseases. Pro-gress in Retinal and Eye Research 66, 1–16 (2018) ; 4, Gocho, K. et al. Adaptive Optics Imaging of Geographic Atrophy. Investigative Ophthalmology & Visual Science 54, 3673–3680 (2013); 5, Gale, M. J. et al. Interpretation of Flood-Illuminated Adaptive Optics Images in Subjects with Retinitis Pigmentosa. In Retinal De-generative Diseases 854, 291–297 (2015); 6, Legras, R. et al. Distribution of cone density, spacing and arrangement in adult healthy retinas with adaptive optics flood illumina-tion. PLos One 13(1), 1-13 (2018); 7, Zaleska-Zmijewska, A. et al. Human photoreceptor cone density measured with adaptive optics technology (rtx1 device) in healthy eyes: Standardization of measurements. Medicine 96(25):e7300 (2017)
Duration of Study in the UK
0 years, 9 months, 0 days
Research summary
A special new camera called Adaptive Optics (AO) has been developed which allows us to look at the individual light sensing cells called ‘cones’ and the small blood vessels i.e. tubes which carry blood at the back of the eye in a light sensing structure called the ‘retina’. AO offers a new way of looking at these light sensing cells. Prior to the invention of this technology the light sensing cells could only be seen under the microscope. Both the light sensing cells ‘cones’ and the blood vessels are affected in many different conditions affecting the retina. Damage to these structures could result in a loss of vision. We will be evaluating new ways in which this special camera can be used to help monitor, analyse and assess retinal disease. We will also be assessing the relationship between this new special camera AO and the current technology in use for imaging the retina.
REC name
South Central - Hampshire B Research Ethics Committee
REC reference
20/SC/0064
Date of REC Opinion
16 Apr 2020
REC opinion
Further Information Favourable Opinion