TMS for Pain in Parkinson's Disease. Version 1.0

• Research type

  Research Study

• Full title

  Open-label pilot study using repetitive transcranial magnetic stimulation as a treatment for pain in Parkinson’s Disease

• IRAS ID

  235032

• Contact name

  Malcolm Steiger

• Contact email

  malcolm.steiger@thewaltoncentre.nhs.uk

• Sponsor organisation

  The Walton Centre NHS Foundation Trust

• Clinicaltrials.gov Identifier

  NCT03350464

• Duration of Study in the UK

  1 years, 0 months, 0 days

• Research summary

  Parkinson’s disease is a condition that causes difficulties with mobility and tremors. An increased understanding of the condition confirmed that pain is an important symptom in patients who suffer from Parkinson's Disease and is a key unmet need in patient’s care. Despite best medical therapy to control the movement disorder we are still struggling to treat pain in these patients. The evidence for the treatment of pain in patients who suffer from Parkinson's disease is poor and most current available treatments may have significant side effects.
  
  Transcranial magnetic stimulation (TMS) is a procedure that has been shown to improve pain in chronic sufferers. It is a well-tolerated procedure that can be performed on an outpatient basis. It uses a plastic covered coil that sends a magnetic pulse through the skull into the brain and by targeting particular areas in the brain it can be used to help modulate the perception of pain.

  We intend to study the use of this technique to treat such a disabling symptom in patients who suffer from Parkinson's disease. Initially we want to study this technique in ten patients. These patients would initially require an MRI scan which allows us to map the brain and target the correct brain areas for the delivery of the stimulation. The stimulation would be performed over twelve sessions and the patients would be assessed by a clinician using well recognised clinical tools.

  We anticipate a meaningful improvement in pain. We also anticipate it is a safe technique to use in patients with Parkinson’s disease. We intend to use this study to help plan a future study that compares Transcranial magnetic stimulation with sham technique to prove whether it could be an option in the treatment of such a disabling condition.

• REC name

  North West - Greater Manchester Central Research Ethics Committee

• REC reference

  18/NW/0027

• Date of REC Opinion

  14 Feb 2018

• REC opinion

  Further Information Favourable Opinion