Tissue collection & bone marrow aspiration at hip replacement surgery
Research type
Research Study
Full title
Collection of waste tissue and iliac crest aspiration of bone marrow at total hip replacement surgery
IRAS ID
181972
Contact name
Andrew McCaskie
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust
Duration of Study in the UK
4 years, 11 months, 30 days
Research summary
This study and ethics application is for tissue sampling whilst patients are undergoing total hip replacement surgery. Tissues to be sampled include (1) bone marrow, (2) waste tissues which are normally discarded following a total hip replacement (e.g. labrum, synovium, excised cartilage/bone, ligaments, capsule), and (3) peripheral blood (20ml).
A bone marrow aspirate is obtained via a needle inserted into the pelvis intra-operatively and drawing up a small volume of the marrow fluid. This is a standard procedure and technique used in the management of haematological disease (normally done under local anaesthetic) As our patients will be under a general/regional anaesthetic for their hip replacement, the bone marrow aspiration will not cause any additional discomfort.
Adult stem cells occur in many tissues and can differentiate into specialised cells in their tissue of origin or differentiate into cells characteristic of other tissues. Adult stem cells are already used to treat haematological malignancies and have huge applications in the field of tissue engineering and regenerative medicine, in particular the regeneration of bone and cartilage tissues in osteoarthritis. We aim to harvest stem cells from these tissues to better understand the resident cells, including mature and progenitor cells from mesenchymal/stromal and haematopoietic systems. Through this, we aim to increase a mechanistic understanding of the interaction of these heterogeneous cell mixtures.
REC name
West of Scotland REC 5
REC reference
16/WS/0175
Date of REC Opinion
8 Sep 2016
REC opinion
Favourable Opinion