Thymoglobulin Induction in Kidney Transplant Recipients

• Research type

  Research Study

• Full title

  THYMOGLOBULINE INDUCTION AND STEROID-FREE IMMUNOSUPPRESSION IN KIDNEY TRANSPLANTATION FROM DECEASED DONORS AFTER CARDIAC DEATH-AN OPEN LABEL RANDOMISED CONTROLLED TRIAL TO EVALUATE THE ROLE OF THYMOGLOBULINE AS INDUCTION IMMUNOSUPPRESSION IN KIDNEY TRANSPLANTS FROM DECEASED DONORS AFTER CARDIAC DEATH (TIKT)

• IRAS ID

  28073

• Contact name

  Peter Friend

• Sponsor organisation

  University of Oxford

• Eudract number

  2009-016676-73

• ISRCTN Number

  not applied

• Research summary

  The increasing disparity between organ availability and the number of waitlisted patients has led to different strategies to improve half-life of all transplants. One such method is to reduce the amount of damage the organ sustains during the period of preservation and reperfusion in the recipient. Thymoglobuline, an anti-lymphocyte antibody has been shown to have the ability to reduce this damage in experimental studies. This study aims to ascertain the role of Thymoglobuline in kidney transplants from donors after cardiac death, the type of kidney transplants at highest risk of sustaining injury during preservation. The study will involve comparison with conventional immunosuppressant therapy, comparison between Thymoglobuline administered in different doses, and observation of the patterns of blood cell repopulation (lymphocytes mainly) in the first year following kidney transplantation.

• REC name

  South Central - Oxford A Research Ethics Committee

• REC reference

  10/H0604/93

• Date of REC Opinion

  8 Feb 2011

• REC opinion

  Further Information Favourable Opinion