Thrombectomy Clots Collection
Research type
Research Study
Full title
Collection of thrombectomy clots from patients with acute ischaemic stroke
IRAS ID
328538
Contact name
Craig Smith
Contact email
Sponsor organisation
The University of Manchester
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
The main purpose of this study is to build a collection of clots (thrombi) retrieved from patients with ischaemic stroke to increase our understanding of thrombus composition and aid development of new clot-busting (thrombolytic) drugs to help break down thrombi in future stroke patients. A research team will collect the thrombi immediately following patient consent and urgent clinical thrombectomy procedures and perform laboratory tests (ex vivo) to assess the thrombi composition, and measure thrombi response to different drugs. Routinely collected data from medical records will also allow the research team to investigate any possible relationships between patient clinical factors and responses of thrombi to drug testing in the ex vivo experiments. Whilst this study will be of no benefit to the participants, the provision of fresh thrombi will allow the team to investigate the detailed composition of thrombi, which will aid and inform development of potential new clot-busting treatments. The study will also provide the opportunity to test the effectiveness of already-identified potential thrombolytic agents.
Eligible patients are adults who have presented at Salford Royal Hospital (SRH) with an acute ischaemic stroke, and who will undergo thrombectomy procedures. The study will be conducted at SRH (retrieval of clots, initial laboratory testing) and laboratories at the University of Manchester (further laboratory testing). Participants will be approached and informed consent taken for the study team to retain the clot post-thrombectomy and access medical records. After this, there will be no further contact with participants. The study will last for the time required to collect the required number of clots (100) and the laboratory analyses to be completed, which will be up to one year following the last recruited participant.
REC name
Wales REC 3
REC reference
23/WA/0318
Date of REC Opinion
15 Nov 2023
REC opinion
Favourable Opinion