Thermocoagulation for the treatment of high grade CIN
Research type
Research Study
Full title
Clinical effectiveness of thermocoagulation in the treatment of high grade cervical intraepithelial neoplasia (CIN): A data linkage study
IRAS ID
255457
Contact name
Maggie Cruickshank
Contact email
Sponsor organisation
University of Aberdeen
Duration of Study in the UK
0 years, 10 months, 30 days
Research summary
Current treatment for cervical intraepithelial neoplasia (CIN; also known as pre-cancerous lesions) is by local thermal ablation (also called thermocoagulation or cold-coagulation) or excision of the transformation zone of the cervix (TZ).
There is currently a lack of long-term data on the effectiveness of treatment by thermocoagulation on women who have been treated for cervical abnormalities.
This study will use routinely collected data from Scotland to help fill this evidence gap. There are two relevant national data-sets: NCCIAS (National Colposcopy Clinical Information and Audit System; containing colposcopy records, including colposcopy results, treatment and histology) and SCCRS (Scottish Cervical Call Recall System, containing cervical screening data, including dates of tests and the results of these tests). Data from both data-sets contain the Community Health Index (CHI) number and so can be linked.
Women who have had treatment for histologically confirmed CIN from 1 January 2005 to 31 December 2014 will be identified from national colposcopy records. Within the Grampian Safe-Haven, this will be linked to any subsequent colposcopy episodes and subsequent screening data.
On the basis of the subsequent colposcopy and screening data, women will be classified as being disease free during follow-up, or having a histologically confirmed CIN diagnosis during follow-up after treatment. The proportion of women who had their initial treatment by thermocoagulation who have histologically confirmed CIN during follow-up will be compared to the proportion of women who had their initial treatment by excisional treatment who have histologically confirmed CIN during follow-up.
REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
18/NW/0799
Date of REC Opinion
4 Dec 2018
REC opinion
Favourable Opinion