Therapeutic ultrasound for sinusitis in cystic fibrosis

• Research type

  Research Study

• Full title

  A randomised trial of therapeutic ultrasound for chronic rhinosinusitis in adults with cystic fibrosis

• IRAS ID

  107301

• Contact name

  Louella O'Herlihy

• Contact email

  louella.o'herlihy@poole.nhs.uk

• Sponsor organisation

  Poole Hospital NHS Trust

• Research summary

  Cystic fibrosis is a genetically inherited disease that affects multiple body systems. The respiratory system develops chronic lung infection, causing progressive respiratory failure. Improved management and survival means that common comorbidities in cystic fibrosis have a more chronic impact on the patient. One of the most common comorbidities is rhinosinusitis, defined as inflammation of the nasal cavity and paranasal sinuses. Chronic rhinosinusitis may worsen respiratory pathology because there is potential for chronic infection in the sino-nasal cavities to continually re-seed the lungs with bacteria through the ’united airway’. Chronic rhinosinusitis and worsening respiratory pathology are each associated with a reduction in quality of life in people with cystic fibrosis. The aims of treatment that are recommended in rhinosinusitis in people with cystic fibrosis are to reduce mucus viscosity, relieve obstruction, clear infection, and reduce inflammation, thereby improving quality of life.

• REC name

  North of Scotland Research Ethics Committee 2

• REC reference

  13/NS/0127

• Date of REC Opinion

  17 Sep 2013

• REC opinion

  Favourable Opinion