The Water Drinking Test In Glaucoma Study: WIGS
Research type
Research Study
Full title
The Water Drinking Test In Glaucoma Study (WIGS): Agreement of peak intraocular pressure measurements during the water drinking test and the modified diurnal tension curve, and its predictive value for glaucoma progression.
IRAS ID
264273
Contact name
Maria Francesca Cordeiro
Contact email
Sponsor organisation
Imperial College London
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 3 months, 28 days
Research summary
Research Summary
Intraocular pressure (IOP) is the main risk factor for glaucoma. Evidence shows that only seeing patients in clinic may miss raised eye pressure in 30% of patients. This is because eye pressure normally varies throughout the day. This raised pressure that is not recorded in clinic may be responsible for worsening of disease. Measuring eye pressure multiple times throughout the day (‘phasing’) is often used in regular care to provide more reliable measurements. However, this is time-consuming and may also fail to detect small rises in pressure. The alternative Water Drinking Test (WDT) involves the patient drinking 800mL of water within 5 minutes. This simple test has been observed to temporarily raise eye pressure to a level similar with the ones that actually occur during the day regardless of the time it is performed and can be completed in a shorter time period.
The purpose of this study is to compare the pressure recorded during the two tests and evaluate any differences. This will help us to decide the best way to measure rises in eye pressure in our glaucoma patients.
The participants' follow-up data which is routinely generated as part of the glaucoma care pathway e.g. visual fields, IOP, will be accessed for 18 months following completion of participation with a view of correlating initial results with possible disease progression and other related outcomes. Permission to access the relevant data will be documented in the informed consent form; patients will be informed that this is optional.
Summary of Results
This study found a strong correlation between maximum Intraocular pressure measured during the modified diurnal tension curve and the water drinking test using multimodal observer-masked tonometry measurements of intraocular pressure, in addition to the association with several physiological parameters.
REC name
London - Harrow Research Ethics Committee
REC reference
20/LO/0035
Date of REC Opinion
3 Mar 2020
REC opinion
Further Information Favourable Opinion