The Use of the Anti-Xa Assay to Monitor UFH
Research type
Research Study
Full title
The Use of the Anti-Xa assay to Monitor the Anticoagulant Effect of Unfractionated Heparin During Cardiopulmonary Bypass.
IRAS ID
262689
Contact name
Jennifer Travers
Contact email
Sponsor organisation
Golden Jubilee Foundation
Duration of Study in the UK
1 years, 0 months, 23 days
Research summary
The study will involve analysis and comparison of coagulation tests used during cardiac surgery on patients who are on cardiopulmonary bypass (CPB) during their procedure.
Coagulation tests are used to test how long it takes for a blood clot to form and are important during CPB to ensure the patient does not clot or bleed excessively. Currently, during CPB the patient’s coagulation is tested routinely using a point of care test (POCT) within theatre to measure their response to heparin which is given before CPB commences.
However, the results from these POCTs can be prolonged for several reasons, for example, if the patient has a deficiency of one of their coagulation factors making the test unreliable in these cases.
For this study 3 extra blood samples will be taken at 3 time points during the operation (after heparinisation and pre/post protamine neutralisation). The three extra blood samples will be analysed in the haematology lab. The routine POCT tests will be tested as standard practice.
Baseline and post operative coagulation samples (2 samples in total) are routinely taken for clinical purposes. An Anti-Xa will also be tested on these samples to obtain baseline and post op levels.
None of these laboratory tests will be used in the management of the patients. This is purely for a range finding study for the laboratory.
The study will only be carried out within the Golden Jubilee National Hospital and is expected to last for roughly twelve months from the date of starting.
REC name
North West - Greater Manchester Central Research Ethics Committee
REC reference
19/NW/0675
Date of REC Opinion
6 Nov 2019
REC opinion
Favourable Opinion