The TASQ Registry
Research type
Research Study
Full title
Validation of the “Toronto Aortic Stenosis Quality of Life Questionnaire” in patients undergoing Surgical Aortic Valve Replacement or Transfemoral Transcatheter Aortic Valve Implantation - The TASQ Registry
IRAS ID
230781
Contact name
Simon Kennon
Contact email
Sponsor organisation
IPPMed
Clinicaltrials.gov Identifier
NCT03186339, clinicaltrials.gov
Duration of Study in the UK
0 years, 7 months, 0 days
Research summary
It is important to capture the disruptions caused by a chronic disease and its treatment on lifestyles, activities, and interests; that is, interference with psychologically meaningful activity. It has been noted that this interference varies by disease process and treatment.
Current questionnaires regarding quality of life do not accurately reflect the difficulties associated with severe aortic valve disease and its treatment. The “Toronto Aortic Stenosis Quality of Life Questionnaire” (TASQ) is a health-specific measurement tool designed specifically to measure changes in quality of life in aortic stenosis patients. As with any new questionnaire, validation in a large group of patients is necessary.
Patients with aortic stenosis will be enrolled in the TASQ registry prior to undergoing a procedure for replacing their diseased aortic valve. This treatment may be surgical or percutaneous (transfemoral transcatheter aortic valve implantation [TAVI]). A further group will consist of patients who are at too high a risk for such interventions and will be treated with medication. The decision as to the most appropriate treatment option will be made by the Heart Team at the institution, completely independent of the study.
Patients will complete the TASQ as well as two commonly used health-related quality of life questionnaires prior to their intervention and again at discharge from hospital, after 30 days and after 3 months. This will enable assessment of how the treatment affects quality of life over time. The results of the TASQ will be compared to those of the two other questionnaires, and its accuracy will be evaluated. Changes in quality of life between the surgical and percutaneous interventions and medical management will then be investigated.REC name
North West - Preston Research Ethics Committee
REC reference
17/NW/0565
Date of REC Opinion
4 Oct 2017
REC opinion
Favourable Opinion