The study of wound healing using a 3D engineered skin model 1.0
Research type
Research Study
Full title
The use of a tissue engineered 3D skin wound model to study and investigate wound healing processes and test newly synthesised wound dressings/ products aimed to promote wound healing.
IRAS ID
346587
Contact name
Karima Bertal-Ngaage
Contact email
Sponsor organisation
University of Huddersfield
Clinicaltrials.gov Identifier
NA, NA
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
The largest organ of the body is skin. Therefore, the wellbeing and normal functioning of an individual physiologically and socially depends on the appropriate healing of this organ. Wound healing is a complex and multi-factorial process, therefore, creating a perfect in vitro wound healing model to mimic the in vivo situation can be a very tedious task.
Animal models are often used as wound healing models but it is uncertain whether these translate into the human scenario.
Hence, having an in vitro working model of a human wound could significantly improve the pre-clinical phase of research.
Our initial proof of concept will aim to produce a 3D engineered skin model, to which a wound will be introduced using initially a scalpel (introducing a burn or infecting the model with bacteria might also be considered at a later stage).
The model will then be used to compare the healing process using various skin cell types. The model will be constructed using tissues from both healthy patients but also from patients suffering from diabetes or severe scarring where wound healing is often impaired. A novel 3D printed dressing developed by the university of Huddersfield will also be tested using this model to demonstrate its potential use in wound dressing assessments.REC name
London - Fulham Research Ethics Committee
REC reference
24/PR/1151
Date of REC Opinion
30 Sep 2024
REC opinion
Favourable Opinion