The role of physical activity and diet within Pulmonary Sarcoidosis

• Research type

  Research Study

• Full title

  The role of non-pharmacological rehabilitation (physical activity and diet) within Pulmonary Sarcoidosis

• IRAS ID

  233621

• Contact name

  Hannah Jayne Moir

• Contact email

  H.Moir@kingston.ac.uk

• Sponsor organisation

  Kingston University, London

• Duration of Study in the UK

  0 years, 6 months, 28 days

• Research summary

  Sarcoidosis is a non-caseating granulomatous disease that involves the inflammation of organs and tissues (Morand et al., 2015). Up to 90% are pulmonary cases, affecting a significant number of people globally, being second to asthma in young adults for respiratory diseases (Morgenthau & Iannuzzi, 2011). There is limited research into the condition as well as clear novel treatments to alleviate the primary and secondary symptoms. Therefore understanding therapies (such as through diet and physical activity) to help the condition but also prevent further reductions in quality of life (QOL) are needed. Reductions in exercise capacity and muscle strength are known primary symptoms of Sarcoidosis (Spruit, 2005a; Hildebrand et al., 2012; Baughman, 2013), which progressively deteriorate with the onset of secondary symptoms such as deconditioning (Mitchell et al., 2012; Fleischer et al.,2014). Currently though it is not clear the degree to which muscle weakness, cardiorespiraotory issues affect exercise capacity in sarcoidosis and specific dietary and exercise recommendations are limited by the lack of evidence for specific modifications such as the type(s), intensities, frequency and duration (Strookappe et al., 2015).
  The aim is to determine the interaction of dietary patterns and physical activity levels within pulmonary sarcoidosis. The primary aim is to ascertain the physical activity patterns, while the secondary aim is to understand the effect of pulmonary sarcoidosis in relation to muscle strength and exercise capacity, lung function and oxygen saturation. Key outcomes will establish trends in relation to environment, diet, physical activity and personal views of day-to-day experiences as well as demographic data and clinical status (age, gender and ethnicity); body fat percent, lung function (forced vital capacity), functional exercise capacity assessed by six-minute walk test, muscle strength by isokinetic dynamometer and hand dynamometer, patient reported health status and pulmonary complaints objectified in disease-specific quality of life questionnaires.

• REC name

  London - Surrey Research Ethics Committee

• REC reference

  17/LO/1440

• Date of REC Opinion

  19 Sep 2017

• REC opinion

  Unfavourable Opinion