The role of PDE-10A in Parkinson’s disease L-dopa-induced dyskinesias.
Research type
Research Study
Full title
The role of phosphodiesterase 10A (PDE-10A) in Parkinson’s disease L-dopa-induced dyskinesias.
IRAS ID
129568
Contact name
Marios Politis
Contact email
Sponsor organisation
Imperial College London and Imperial College Healthcare NHS Trust
Research summary
Following some years of levodopa treatment, people with Parkinson’s disease (PD) develop disabling involuntary jerky movements called dyskinesias (LIDs). Dyskinesias hamper the clinical management of PD having a negative impact on the quality of life for people with PD. Currently there is no effective treatment and the mechanisms responsible for the development of dyskinesias are unknown. In this study we follow promising work on animal models of PD and we aim to investigate the role of the novel target called phosphodiesterase 10A(PDE-10A), which we believe that the hyperactivity of this enzyme in the brain of people with PD is responsible for development of dyskinesias. We will investigate PDE-10A expression in the brain of PD patients using a special type of brain scan called positron emission tomography (PET). The implications of this novel research study may lead to important advances in PD clinical management by revealing the mechanism responsible for dyskinesias. The outcome of this research study will hopefully benefit the lives of PD patients.
REC name
London - Surrey Borders Research Ethics Committee
REC reference
13/LO/0863
Date of REC Opinion
18 Jul 2013
REC opinion
Further Information Favourable Opinion