The role of neuronal NOS in the regulation of brain perfusion
Research type
Research Study
Full title
The role of neuronal nitric oxide synthase in the regulation of brain perfusion
IRAS ID
231061
Contact name
Ajay Shah
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
0 years, 11 months, 28 days
Research summary
It is known from animal studies that an enzyme called neuronal nitric oxide synthase (nNOS) plays an important role in many brain functions. Our research group has recently demonstrated the safe use of a drug called S-methyl-L-thiocitrulline (SMTC) to block the action of nNOS, and has subsequently used SMTC in human studies on the heart and blood vessels. This study will use SMTC to investigate the role of nNOS in the regulation of brain blood flow in healthy humans, measured by MRI scanning.
REC name
London - Queen Square Research Ethics Committee
REC reference
18/LO/0732
Date of REC Opinion
1 Jun 2018
REC opinion
Further Information Favourable Opinion