The role of inflammation in cardiovascular disease
Research type
Research Study
Full title
The role of inflammation in cardiovascular disease: identification of new therapeutic targets
IRAS ID
273924
Contact name
Ziad Mallat
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
One of the main aspects of the pathophysiology of atherosclerosis and aneurysms is the chronic inflammation of the arterial wall. Atherosclerosis is responsible for most ischaemic cardiovascular diseases and stroke, the most frequent causes of death worldwide, while aortic aneurysms (AAA) rupture account for the 10th leading cause of deaths in men older than age 55. It has become clear that the immune system cells play a critical role in disease and we wish to understand how these cells contribute to this inflammation. Our particular focus has been to utilise animal models to investigate which immune cell subsets play a role in atherosclerosis and AAA development and what factors drive them to contribute to disease. The purpose of this research using discarded tissue from interventional surgery is to perform in vitro approaches to determine the relevance of these cells and pathways in humans.
REC name
London - Bloomsbury Research Ethics Committee
REC reference
21/PR/1297
Date of REC Opinion
7 Oct 2021
REC opinion
Further Information Favourable Opinion