The Role of Diabetic Stimuli on kidney resident cells
Research type
Research Study
Full title
The Role of Diabetic Stimuli on the interactions between human macrophages and tubule epithelial cells.
IRAS ID
130153
Contact name
Rosa M Montero
Contact email
Sponsor organisation
Epsom & St Helier University Hospital NHS Trust
Research summary
The aim of this research is to understand how cells identified in inflammation and wound healing interact with kidney cells in diabetic conditions; to explain why there is the formation of scarring leading to the loss of kidney function and to see if these processes reveal potential targets for new treatment options for patients with diabetic kidney disease. Macrophages are inflammatory cells of the body that have been found in the kidneys of people with diabetes. Very recent evidence suggests a correlation of macrophages and the decline in renal function in these patients. It is not clear how macrophages communicate and interact with the kidney cells and whether this causes damage to the kidneys. Human blood macrophage cells and kidney cells from the laboratory will be mixed together to see how they interact and to see if they increase the markers of inflammation and scarring that cause damage to the kidneys.
REC name
London - Surrey Borders Research Ethics Committee
REC reference
13/LO/1138
Date of REC Opinion
11 Oct 2013
REC opinion
Further Information Favourable Opinion