The role of circuit flow during mechanical ventilation of neonates
Research type
Research Study
Full title
INVESTIGATING THE EFFECT OF ALTERING THE SLOPE OF THE RISE IN PRESSURE DURING MECHANICAL VENTILATION OF PRETERM BABIES
IRAS ID
207145
Contact name
Gusztav Belteki
Contact email
Sponsor organisation
R & D Department, Cambridge University Hospitals NHS Trust,
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
About 1.5% of newborns require ventilation. While mechanical ventilation can be life-saving, ventilator damage to neonatal lungs has serious, long-term consequences. Few studies have investigated benefits and harms of different settings.
We developed a unique system for collecting data from the Dräger VN500 ventilator used in our Unit and can now study each inflation and breath over long periods of mechanical ventilation. By changing the ventilator circuit flow, we will investigate the effect of the rate of rise (slope) of the inflating pressure on ventilation. No studies have reported the effect of different slope speeds. Guidelines suggest it is set at 0.1 s. This is relatively fast.
We hypothesize a slower slope will distend the lungs more gently yet maintain ventilation.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
16/EE/0327
Date of REC Opinion
5 Oct 2016
REC opinion
Further Information Favourable Opinion