The RECUT Plus Study
Research type
Research Study
Full title
Clonal evolution in cancer for patients undergoing transoral Robotic surgery for radiation Exposed residual/reCurrent tumours of the Upper aerodigestive Tract.
IRAS ID
280262
Contact name
Vinidh Paleri
Contact email
Sponsor organisation
The Royal Marsden NHS Foundation Trust
Duration of Study in the UK
6 years, 0 months, 1 days
Research summary
Radical radiotherapy for head and neck squamous cell cancer (HNSCC) can be administered to primary disease with curative intent. Residual disease, recurrence or further tumours may subsequently occur in this irradiated field. It is unknown whether these cancers reflect primary resistance or represent the evolution of resistance on treatment. Understanding this could allow stratification of patients to more effective primary treatments, such as transoral robotic surgery, or help tailor systemic therapies for these cancers in previously irradiated fields.
RECUT+ is an exploratory molecular analysis study to assess the selective impact of radiation therapy on HNSCC.
Participants will be recruited from the Royal Marsden Hospital (RMH), Chelsea, a tertiary referral H&N cancer unit in London, UK, specialising in transoral robotic surgery.
Retrospective participants will be identified as per the RECUT main study (IRAS 268830) from an existing prospectively collected database.
Prospective participants will be screened for by the RECUT+ team during the weekly H&N MDT meetings at the Royal Marsden Hospital (RMH).Blood/saliva samples will be collected pre operatively (prospective participants) and post operatively (retrospective and prospective participants) for germline and circulating tumour DNA analysis.
Biospy samples from the original cancer and resected specimens from the post radiotherapy residual/recurrent/new primary disease will undergo molecular analysis to assess for any selective impact of radiotherapy on these further tumours.
REC name
South Central - Berkshire B Research Ethics Committee
REC reference
20/SC/0297
Date of REC Opinion
28 Jul 2020
REC opinion
Favourable Opinion