The Prevalence of HGD/OAC in Barrett's LGD/IND
Research type
Research Study
Full title
A cohort study to determine the prevalence of high grade dysplasia and oesophageal adenocarcinoma in Barrett's associated low grade dysplasia and indefinite for dysplasia.
IRAS ID
207085
Contact name
Edward Cheong
Contact email
Sponsor organisation
Norfolk and Norwich University Hospital NHS Foundation Trust
Duration of Study in the UK
0 years, 2 months, 1 days
Research summary
Cancer of the gullet, Oesophageal Cancer (OC) continues to have a poor prognosis. Barrett's oesophagus is known as the only identifiable pre-cancerous condition which has the potential to develop into the commonest type of OC, oesophageal adenocarcinoma (OAC). Patients with Barrett’s oesophagus often undergo endoscopic surveillance to detect dysplasia and malignancy at a more readily treatable stage. Barrett’s oesophagus is either classified as having no dysplasia, indefinite for dysplasia, low-grade dysplasia, and high-grade dysplasia, with higher grades associated with the greatest risk of malignant transformation. Current surveillance guidelines for indefinite for dysplasia and low-grade dysplasia, particularly the intervals of endoscopic surveillance, are based on the incidence of malignancy for these groups. The prevalence of malignancy could feasibly also inform optimum intervals of endoscopic follow-up particularly in the immediate period after diagnosis. There are however limited data on the prevalence of malignancy in these two groups. Our study aims to report the prevalence of high-grade dysplasia and OAC in these two groups. The study will use an existing dataset collected for the purpose of a clinical audit at the Norfolk and Norwich University Hospital.
REC name
London - Chelsea Research Ethics Committee
REC reference
17/LO/2054
Date of REC Opinion
22 Nov 2017
REC opinion
Favourable Opinion